DRUG SAFETY SCIENCES – PROFESSOR MUNIR PIRMOHAMED
Professor Pirmohamed, also Consultant Physician at the Royal Liverpool University Hospital, holds the only NHS Chair in Pharmacogenetics in the UK and is Director of the Medical Research Council’s Centre for Drug Safety Sciences. He has been recognised with a knighthood for his services to medicine.
The P450 tests should be given BEFORE PRESCRIBING to everyone and are available under the NHS so please contact me if you are refused such tests. I know they are adopted by NHS because I checked with Liverpool University only recently.
Some more good publications by Catherine Clarke below:
http://www.psychiatric-drug-effects.com/?
Carer_and_Patient_Mental_Health_Awareness_Series___Psychological_Therapies_Awareness -its an eye opener. CBT ruling the roost in NHS/DH; seems drug companies fund this area, as CBT promote the drugs within therapy.
CYP2D6 PM, CYP2C19 IM and SLC6A4 (5-HTT) Intermediate Serotonin Transporter SA/LA.
P450 Liver Enzyme Tests for Elizabeth:
It is also no wonder Elizabeth changed beyond recognition also on Prozac and a multitude other drugs – in fact all have had a non existent or very bad effect. It actually is reported in her file notes to this effect on all the drugs she has been experimented on and how they were ineffective. I reckon she is a NON metaboliser in that case.
I turned to Liverpool University in desperation as I heard of the brilliant research being done by Professor Munir Pirmohammed. This was around 2015. I asked if I could pay for Elizabeth to be tested but instead he went out of his way to help me and introduced me to a Professor in Rotterdam, Erasmus. All it involved was having a cheek swab which I had done at the London Dr’s clinic and then a kit came from Rotterdam. I was astonished the NHS could not help me at the time and was most impressed with the London Doctor’s Clinic and the results speak for themselves.
Elizabeth needs a close examination of the temporal lobes which I suspect will indicate inflammation. If this is the case there is no wonder she cannot progress. She almost certainly needs anti-inflammatory drugs far more than she needs anti-psychotics that actually cause inflammation.
If they are ignoring ghosting on the scans they are being negligent. She is already established as a poor metaboliser because of low expression of P450 cytochromes. Compound that with neuroleptic induced inflammation and we have a ‘perfect explanation’ of why they have made no progress in her mental health recovery. They have in fact not really tried at all.
Ignoring pathophysiological symptoms and markers is utterly absurd in any diagnostic system let alone the potential for consequences of ignoring them when administering medication.
Refusing Elizabeth and other patients access to properly conducted tests and analysis is a scandal on a huge scale. But of course they find it much easier to label people with catch-all and non specific stigmatising terms like schizophrenia.
It is entirely possible that Elizabeth suffered a decreases in cerebral glucose metabolism at the time she was originally wrongly diagnosed with schizophrenia.
That has been shown in the medial temporal lobe and increases have been seen in the subgenual anterior cingulate cortex in conjunction with reductions in mesolimbic connectivity, following an induced inflammatory response. Trauma can induce this inflammatory response.
It is further possible that millions of young people have been so diagnosed because the NHS is obsessed with focussing solely on the psychiatric symptoms while positively avoiding pathophysiological and trauma induced causes of psychosis.
The mesolimbic system is precisely where dopaminergic activity is taking place and inflammation will obviously interfere with that, causing manifestations of psychosis. If the inflammation had been addressed with anti-inflammatory drugs at onset a lifetime of psychosis and consequent drugging could have been avoided.
I suspect that Elizabeth will express C-reactive proteins and interleukin 6, just as she was shown to be a poor metaboliser. Both of these are a result of her genotype and her treatment should have been based on these. Undoubtedly the NHS will refuse to test her for these markers.
Instead they cling on to the outdated and hideous system of labelling people with schizophrenia and dosing them with anti-psychotic medication.
If they have identified no physical health concerns it is because they are not carrying out the correct tests. She will have some degree of endocrine dysfunction and potentially inflammatory conditions. These all are affected by the use of neuroleptics and concomitantly affect the drug metabolism. The drugs have a long established record of causing in some cases irreversible neural damage and physiological damage due to anti-muscarinic ARD’s.
It is utterly preposterous to suggest that neuroleptics “aid mental health recovery”. They are of use only in the short term in mental health crisis and the Harrow Study, and many others like it show that long term use is far less effective than withdrawal from the drugs at an appropriate time. The drugs are a chemical straightjacket and I know of not one study in over 70 years of the use of these drugs that shows a patient being ‘cured’ or ‘recovering’.
Up-regulating or down-regulating dopaminergic & 5-HT neurotransmitters does not ‘cure’ illnesses that have a pathological cause. The so called chemical imbalances they say they are treating have an underlying pathophysiological cause which they completely ignore. Unlike the belief system that they adhere to there is a mountain of evidence in the medical literature that shows this. They simply and blatantly ignore the effects of inflammatory conditions in spite of it being demonstrable that they cause disruption to neurotransmission function. They ignore the P450 cytochromes and all long-determined methods of titration and serum count influencing minimum effective dose. They ignore the fact that in over 100 years no one has been able to identify this ‘disease’ they call schizophrenia by any proper cause or aetiology. For 40 years at least they have said it is genetic but apart from a few dodgy twin studies have never proved it and have never even identified the ‘defective gene’ that they blame.
The fact that they disregard neurological conditions as a cause of psychosis beggars belief itself. The drugs they use target the neurotransmission system in the brain but at the same time they claim the mental illnesses don’t have a pathophysiological cause, except for this unproven and utterly unscientific claim of chemical imbalances. Not one of the chemical imbalance ‘theories’ has ever identified what this idiotic mantra actually means. What exactly is the correct ‘balance’ they are talking about? Psychiatry is about 30 years behind neuroscience and all neurology researchers are expected to prove their assertions by scientific method. Not so psychiatrists, who are quite happy with what they believe.
If a cure for mental illness is ever found it will be found by neurologists and those researching neuroscience, not by the headshrinkers who are only interested in locking people away and doping them up to keep them compliant. In general medicine we have lots of drugs that do actually cure people of their illnesses. There is not one psychopharmaceutical product that comes anywhere near that.
What is even more incredible is that their almost religious belief in psychopharmaceutical interventions carries on while they ignore the warnings, ADR’s and contraindications in the very formularies themselves. That is about the only evidence there is of ‘split personalities’, they believe in drugs but don’t believe in the science of pharmacology. They ignore the licensing conditions imposed by the regulators and prescribe drugs that the formularies state should not be prescribed concomitantly. If any of this crazed pseudo cult like behaviour was going on in general medicine we would have a casualty rate among patients that resembled that of the First World War.
Clopixol depot, Haloperidal and Lorazepam:
Elizabeth is treatment refractive, to use that ridiculous expression, which in reality means that the patient cannot metabolise drugs due to CYP450 deficiencies. In that case the Haloperidol and or the Clopixol will do no good at all. A patient who is poorly expressing P450IA2 & P4502D6 will have difficulty metabolising or may not be able at all to metabolise Haloperidol.
P4503A4 is necessary for the metabolism Lorazepam
Clopixol needs P4502D6 & P4503A4.
If those cytochromes are poorly expressed or not expressed at all the patient CANNOT metabolise the drugs then the patient may have metabolic syndrome which is characterised by weight gain, abdominal obesity, a decreased ability to process glucose (insulin resistance), dyslipidemia (unhealthy lipid levels), and hypertension.
This is probably why they do not want Elizabeth seeing endocrinologists, immunologists and neurologists. They would observe these symptoms.
Have had private tests done for Endocrinology and private MRI scans which show the above to be true. Elizabeth is being refused Endocrinology tests and she should also see an Immunologist and Geneticist likewise.
One of the best books in many years Deprescribing in Psychiatry, written by psychiatrists and medical scientists (Gupta, Miller and Cahill) advises strongly against polypharmacy with anti-psychotic medicines. Risk/benefit ratios shift dramatically to the risk in polypharmacy. Clopixol and Haloperidol are both AP’s. Most enlightened psychiatrists are now advocating abandoning polypharmacy and titrating to minimum effective doses, which in most cases are well down towards the lowest end of the daily dose
The doctors at Ash Villa and Castle Ward LPFT should read it.
And perhaps this too.
Metabolic syndrome and mental illness
- PMID: 18041878
- Am J Manag Care. 2008 Feb;14(2):76
Abstract
Patients with mental illnesses such as schizophrenia and bipolar disorder have an increased prevalence of metabolic syndrome and its components, risk factors for cardiovascular disease and type 2 diabetes.
Although the prevalence of obesity and other risk factors such as hyperglycemia are increasing in the general population, patients with major mental illnesses have an increased prevalence of overweight and obesity, hyperglycemia, dyslipidemia, hypertension, and smoking, and substantially greater mortality, compared with the general population. Persons with major mental disorders lose 25 to 30 years of potential life in comparison with the general population, primarily due to premature cardiovascular mortality.
The causes of increased cardiometabolic risk in this population can include nondisease-related factors such as poverty and reduced access to medical care, as well as adverse metabolic side effects associated with psychotropic medications, such as antipsychotic drugs.
Individual antipsychotic medications are associated with well-defined risks of weight gain and related risks for adverse changes in glucose and lipid metabolism. Based on the medical risk profile of persons with major mental illnesses, and the evidence that certain medications can contribute to increased risk, screening and regular monitoring of metabolic parameters such as weight (body mass index), waist circumference, plasma glucose and lipids, and blood pressure are recommended to manage risk in this population.
Treatment decisions should incorporate information about medical risk factors in general and cardiometabolic risk in particular. In addition to the implications for individual clinicians, the problem of disparity in meeting healthcare needs for persons with mental illness in comparison with the general population has become an important public policy concern, with recent recommendations from the National Association of State Mental Health Program Directors and the Institute of Medicine. This article provides an overview of cardiometabolic risk in patients with major mental illness and describes steps for risk reduction.
Psychiatric Abuse UK 